Study Supports Rabies Immunoglobulin for Post-Exposure Prophylaxis in Kids

NEW YORK (Reuters Health) – In children with confirmed or suspected rabies, human rabies immunoglobulin (HRIG) appears to be an effective part of the post-exposure prophylactic (PEP) treatment, researchers say.

“We know the incidence of kids being exposed to animals that may transmit rabies is high,” Dr. Novinyo Amega of Kedrion Biopharma, in Fort Lee, New Jersey, told Reuters Health by email. “However, little data exist that can help clinicians better understand the safety profiles of the various HRIG products currently available.”

Dr. Amega and colleagues conducted a phase-4 prospective, single-arm clinical trial of KEDRAB, an HRIG distributed by Kedrion Biopharma and approved by the U.S. Food and Drug Administration (FDA) in 2017, in 30 patients under 17.

All participants had confirmed or suspected rabies exposure in which PEP was indicated. This included standard-of-care wound washing, passive immunization with HRIG, and induction of active immunity through initiation of the rabies vaccine series. No placebo group was used, as this would have been ethically unacceptable due to the high fatality rate of rabies, the researchers say.

Participants received 20 IU/kg of HRIG150 (150 IU/mL) infiltrated into the wound site or sites. Any remainder was injected intramuscularly, concomitantly with the first of a four-dose series of rabies vaccine. Rabies virus neutralizing antibody (RVNA) titers and tolerability were assessed on day 14 following administration of the last vaccine dose.

There were no serious adverse events, rabies infections, or deaths, the researchers report in Human Vaccines and Immunotherapeutics. Twelve participants experienced a total of 13 adverse events deemed related to the study treatment, but all were mild.

By day 14, RVNA levels had reached at least 0.5 IU/mL in all but two of the participants. However, say the investigators, testing was “not repeated subsequently; thus, it remains possible that the two subjects that did not attain the cutoff by day 14 seroconverted by day 30.”

The study results have been submitted to the FDA for review, Dr. Amega said, adding, “we are pleased to see that top-line results of this pediatric study support KEDRAB’s safety profile. Importantly, we believe that meeting the primary objective of this study could further differentiate KEDRAB from other currently available HRIGs in the U.S.”

Kamada Ltd, which manufactures KEDRAB, and Kedrion Biopharma funded the study. Most of the authors are employees of these companies.

SOURCE: https://bit.ly/3u3cvhH Human Vaccines and Immunotherapeutics, online February 9, 2021.

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Kelly Rowland Recalls Her Water Breaking in 6-Year-Old Son Titan's Bed Before Welcoming Baby Noah

https://www.youtube.com/embed/D5cM9S1UvnY

Kelly Rowland is recalling the unexpected moment she went into labor with newborn son Noah Jon.

The "Black Magic" songstress, who welcomed her second son on Jan. 21, tells Extra that her water broke while she was in 6-year-old son Titan Jewell's bed. Rowland shares both boys with husband Tim Weatherspoon.

"Titan is in the process of going from our bed to his bed, so he called, 'Mommy, Mommy,' and I go there in the middle of the night, and next thing I know I was like, 'You need to go get your dad,' " the mom of two says.

The Destiny's Child alum adds that baby Noah "chose the day" of his birth, which was a significant date.

"He came on the 21st, which I thought was so weird, because it was the 21st day in the 21st year in the 21st century," says Rowland. "We were blown away — me and his dad were so blown away by that."

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Kelly Rowland Has Her Baby Bump Painted, Then Cradles Newborn Son in 'Black Magic' Music Video

According to Rowland, Titan is loving being a big brother to Noah so far. In fact, the he even chose his baby brother's name.

"No one's more excited about Noah than Titan," Rowland says. "If Noah cries, if Noah whimpers, if Noah does anything, Titan's like, 'Noah, Noah.' He's such a great big brother. He's been waiting for this moment, waiting!"

Rowland adds of her newborn: "He's so awesome. I'm literally just getting all my little cuddles and kisses in where I can. I'm really grateful he's a healthy baby. He's very alert. He's already lifting that head up."

Celebrity Babies Born in 2021 (So Far!)

Rowland announced the birth of Noah last month on Instagram, sharing an adorable shot of her newborn spending time with Titan. "We are truly grateful," she wrote, going on to note that her son was born at 8:13 p.m. on Jan. 21, weighing 7 lbs., 8 oz., and measuring 19 inches long.

Back in October, Rowland opened up to PEOPLE about expecting her second baby and how her older son was eager to welcome his new sibling to the family.

"Me and my husband were in the middle of COVID just like everybody else … and there's not much to do in the house," she joked at the time. "We were like, 'We'll just try for a baby, we'll see what happens because we don't know how long this is gonna last.' "

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Oxford Launches COVID-19 Vaccine Study in Children

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center.

Oxford University is starting a COVID-19 vaccine study with children and young adults between ages 6 and 17.

At Oxford and three partner sites in London, Southampton, and Bristol, the phase 2 clinical trial will test whether kids and teens have a good immune response to the AstraZeneca vaccine. Previous trials have shown that the shot is safe in children.

“While most children are relatively unaffected by coronavirus and are unlikely to become unwell with the infection, it is important to establish the safety and immune response to the vaccine in children and young people as some children may benefit from vaccination,” Andrew Pollard, PhD, the chief investigator for the trial and a professor of pediatric infection and immunity at Oxford, said in a statement.

The new trial will enroll 300 volunteers, with up to 240 receiving the vaccine. The control group will receive a meningitis vaccine, which is safe in children and produces similar side effects to the COVID-19 vaccine, such as a sore arm.

COVID-19 vaccine trials have included children over age 12, so this marks the youngest group to be tested so far. Pfizer, Moderna, and Janssen have announced plans to start trials in younger children this spring, according to The Washington Post. Widespread vaccination in children likely won’t occur until 2022, the newspaper reported.

The trial launched on Friday, and the first vaccinations are expected by the end of the month. Parents can visit Oxford’s COVID-19 Vaccine Trial website to sign their children up for the study.

“This study will play an important role in helping to protect children in the future,” Grace Li, a pediatric clinical research fellow for the Oxford Vaccine Group, said in the statement.

“We’ve already seen that the vaccine is safe and effective in adults, and our understanding of how children are affected by the coronavirus continues to evolve,” she said.

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Dwayne Johnson Says He's 'Surrounded by Estrogen' at Home but 'Wouldn't Have It Any Other Way'

Dwayne Johnson is sharing some love for his daughters.

The Hobbs & Shaw actor, 48, opened up about having daughters instead of sons in a sweet Instagram post on Friday morning, sharing a photo of himself walking with his daughter, Tiana, 2½, while holding hands. Johnson shares Tiana and Jasmine, 5, with wife Lauren Hashian, and he's also dad to Simone, 19, with ex-wife Dany Garcia.

"Every man wants a son, but every man needs a daughter," he began the caption. "All my girls have become the great equalizers in my life – I'm surrounded by estrogen and wouldn't have it any other way 😊"

He continued, "and man I hope she never gets tired of holding these big ol' dinosaur hands, though I suspect one day she will 🦖🤚🏾☺️"

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Dwayne Johnson Reflects on His Family's Coronavirus Experience: 'We Were on the Fortunate End'

Johnson has long been open about being a dad to all girls, even previously joking that he's unable to "make" boys. Back in December 2017, ahead of his third daughter's arrival, he told The Tonight Show's Jimmy Fallon all about his excitement for raising a third daughter.

"I've got strong swimmers, Jimmy," he said at the time. "I feel good. I was raised by women all my life, basically. And this is my third daughter. [I'm] surrounded by estrogen. Bring on the estrogen!"

That same month, Johnson announced the news of having his third daughter, writing on Instagram at the time: "… And once again, big daddy is completely surrounded by beautiful estrogen and loving, powerful female mana. All girls. One dude. And a boy dog. I wouldn't have it any other way."

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Maci Bookout: I'm 'Interested' in Having More Kids, Considering Adoption

Maci Bookout and Taylor McKinney have closed the door on naturally conceiving another child — but the couple are open to adoption.

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“We’ve always both had that in our minds,” the 16 and Pregnant alum, 29, exclusively told Us Weekly on Tuesday, January 26, while promoting season 9 of Teen Mom OG. “We are still waiting. … Obviously right now is not the time, but yes, we are both definitely still interested and would welcome that in our future.”

Bookout, who is the mother of Bentley, 12, with Ryan Edwards and Jayde, 5, and Maverick, 4, with McKinney, 31, explained, “We’ll revisit it when I feel like[,] when we feel like, we have our three — not under control because I don’t think that will ever happen — but when maybe when Maverick is in school too, and things can kind of get a little bit more structured.”

‘Teen Mom’ Stars’ Best Quotes on Coparenting

The Tennessee native previously told Us Weekly exclusively that she and McKinney didn’t agree on expanding their family.

“We are on different sides of the fence when it comes to that,” the Naked and Afraid alum said in April 2020. “And we’re both also very respectful of how the other one feels about it. We’re on the same page as far as it being OK that we’re on different pages.”

The reality star added, “We talk about it a lot. And, I mean, nothing’s really changed as far as our opinions go, but that’s OK. As time goes on, we’ll come to some sort of actual resolution or agreement. But, I mean, for now, I think just as long as we keep talking about it even when we’re not on the same page, it’s best.”

At the time, Bookout had spoken to her husband about possibly getting a vasectomy.

‘Teen Mom OG’ Tots in Before and After Pics: How They’ve Grown!

On Tuesday, she clarified that she and the motorcycle racer are now “on the same page” about their future family plans. She explained to Us, “He said he’s on whatever page I’m on. So no more babies — biological, anyways.”

Season 9 of Teen Mom OG premieres on MTV Tuesday, January 26, at 8 p.m. ET.

With reporting by Christina Garibaldi

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Synced brains: How to bond with your kids – according to neuroscience

Synced brains: how to bond with your kids – according to neuroscience

Many people across the world are still living under tough restrictions or lockdowns because of the pandemic, staying home as much as possible. This means that a lot of parents are spending more time than ever with their children. But how do you turn that time into a deeper relationship?

New research, simultaneously measuring brain activity of parents and children, offers some insights.

To effectively interact with others, we must establish an emotional connection as well as swiftly and accurately infer each other’s goals and intentions. Research shows that this works best if we coordinate our behaviour and bodily responses. Luckily, we have a natural tendency to get in sync with others. For example, we automatically imitate one another –- with classical examples including laughing and yawning –- and engage in complex patterns of coordinated eye gaze or touch.

We even socially synchronise our physiology, for example, through the alignment of our heartbeats and hormone secretion (such as cortisol and oxytocin). When we bond with others, it is as if our entire body engages in a “social dance”.

Socially dancing with others enables us to more easily feel what they are feeling and think what they are thinking. This process, called bio-behavioural synchrony, helps us to more strongly connect with one another. During childhood, being in sync with others is also vital for social, emotional and cognitive development.

Brain-to-brain synchrony

Researchers have recently started testing what happens in the brain when two people interact in this way. Using functional near-infrared spectroscopy (fNIRS) “hyperscanning”, brain activity can be measured while people are doing various tasks and wearing a cap linked up with optical sensors. This is done for each participant, and brain activity is then compared. Synchrony arises when there are aligned decreases and increases in the same brain area at roughly the same time.

Studies using this approach with adults have shown that brain activity also tends to become coordinated during interactions. Also, brain-to-brain synchrony was found to be higher in romantic partners compared with friends or strangers.

But what about parents and children? Our new research reveals that brain-to-brain synchrony is also increased when both mums and dads interact with their children, especially when they play or solve problems, such as puzzles, together. Tellingly, the stronger the brain-to-brain synchrony, the more problems parents and children can solve. We have also found increased brain-to-brain synchrony in mums and their kids when they talk to each other.

Engaging in activities with one’s children, such as solving problems through play or simply having a conversation, should therefore always be seen by parents as opportunities to strengthen the parent-child bond and help their children develop vital social, emotional and cognitive skills.

Mums and dads

Brain-to-brain synchrony has been observed to be stronger for children interacting with their parents than with an unknown adult. Although this shows that the parent-child relationship is special in terms of coordinated brains—probably reflecting their closer emotional bond—it does not yet reveal much about the relationships’ underlying qualities. When we looked more closely at how brain-to-brain synchrony between parents and their children related to interaction and relationship quality, we found several additional clues. Interestingly, these clues differed somewhat between mums and dads.

We saw stronger brain-to-brain synchrony during both puzzle solving and conversation if mums and kids took more turns, meaning that they performed the task or spoke alternately—or in succession. The same was true when children were able to more strongly engage in the task instead of being led by their mothers, and so given more autonomy.

Conversely, synchrony diminished during puzzle solving when mothers reported being stressed. In such moments, taking a short break and engaging in self-care may be beneficial for both mothers and children.

In father-child pairs, however, we did not find any links between brain-to-brain synchrony and turn-taking, child autonomy or stress. In turn, we saw higher synchrony in those pairs where dads indicated that being involved in childcare is important for child development and rewarding for themselves.

Take-home message

It seems that brain-to-brain synchrony between mums and dads and their children can be achieved by different means. One possible explanation may be that mother-child interactions are marked by more rhythm and structure, whereas father-child interactions may be somewhat jerkier and energetic. Such different experiences enable children to successfully and simultaneously interact with different types of caregivers and practice a variety of social, emotional and cognitive skills.

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LOL! Jessica Alba Disciplines 3 Kids With Help From 'Spy Cameras'

Jessica Alba has got an eye on her kids at all times! The actress has installed cameras around her Los Angeles home.

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“I have spy cameras in their room so I can see [whether] they [are] messing around or … focusing [while doing virtual learning],” the Honest Company creator, 39, said during a Friday, January 15, Ellen DeGeneres Show appearance. “I can call them out. I’m the voice from the ceiling coming in.”

The California native added that when Honor, 12, Haven, 9, and Hayes, 3, bicker, she “can rewind and really see who hit who first.”

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Alba and her husband, Cash Warren, have their hands full at home with their three kids. Their youngest, especially, is “nonstop,” the Fantastic Four star told guest host Stephen “tWitch” Boss. “He literally wakes up, he’s running, he’s throwing ball, he wants to play gold, cars, all of it,” she said.

As for the Golden Globe nominee’s daughters, Honor and Haven are “great” and “different.” Alba explained that her eldest is in “that sweet teen kind of age” and is taller than her mom. “I don’t know how it happened, it happened so fast,” she said. “It’s just like, she’s not the little baby anymore. What happened? I’m looking at her like, ‘You’re bigger than me?’”

Haven is “the best” and loves having a social circle, the L.A.’s Finest star added. “That’s her vibe. She’s really found her way through COVID and all of this and has done it really well.” She has even been teaching her mom TikTok dance routines while quarantining amid the coronavirus pandemic, doing family game nights and binge-watching shows.

Boss, 38, gushed that Alba’s kids have a “boss” mom, but she admitted they call her “so cringey.” She explained that when Honor found out her mom was famous, “she felt so betrayed” and “mortified.”

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The entrepreneur said, “She came home and was like, ‘Why didn’t you tell me? You never told me that you were gonna be in grocery stores or in Target?’ A friend [had] brought a magazine to school and put her on blast and Honor was like, ‘What are you doing on this magazine?’ Then I had to break it to her that I was an actress, sometimes I do the magazines.”

Alba loves being a mom and said during a February 2020 event that a lot of her parenting skills translate to running her company. “It’s more about who you surround yourself with,” the Sin City star said at the time. “The goal you end up reaching is great, you’re only thinking of the next challenge you’re wanting to do and the next goal you want to overachieve and what will come. It’s hard not to be totally and completely overwhelmed.”

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Jessica Simpson Says Hearing Her Kids Laugh Is 'Most Healing Sound': 'Family Is Everything to Me'

A family that laughs together!

Jessica Simpson tells Shape that hearing giggles from her three children — daughters Birdie Mae, 22 months, and Maxwell "Maxi" Drew, 8½, plus son Ace Knute, 7½ — helps her decompress and enjoy her day. The singer shares her trio of laughers with husband Eric Johnson, whom she wed in 2014.

"When I hear my kids cackle, it's the most healing sound," says Simpson. "It's contagious — my whole family starts giggling together, and it's like some form of happy laughing therapy."

The Open Book author also says "family is everything to me" while adding what she hopes to instill in her little ones as they grow up: "More than anything, I want to teach them morals and values and to keep them safe but not afraid."

The mom also explains how she manages to stay grounded after a "busy day of taking care of everyone."

"I started journaling after I wrote my book. It gets my thoughts out and lets me face them on paper. I know I can't carry the weight of the world and all those thoughts all the time," Simpson says. "After a busy day of taking care of everyone, this clears my mind so I can have a restful night of sleep."

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 The Absolute Sweetest Photos of Jessica Simpson's Baby Girl, Birdie

Simpson previously opened up to PEOPLE about her kids, including the joys of watching her older two interact with her toddler. "It's so cute to watch my older kids with her. My son and her are like BFFs! The cutest," she said. "When Birdie is laughing, like cackling, that is a contagious thing throughout the family. Her first word was 'Ace.' "

She added that her "very observant" youngest child "says hi to everybody." "She'll stare you down for a bit and then, 'Hi. Hi.' She's so cute," Simpson said. "She's also a bruiser, she'll just go darting off in one second and you're like, 'Wait, how'd you get all the way over there?' It's crazy. They're growing up so fast."

Simpson also shared details about her time self-isolating at home during the pandemic, saying that it has been a "very enlightening experience, prayerful, [and] a journey for sure." The star shared how engaging in mindful and prayerful talks with Maxwell helps them stay calmed and grounded.

"I put my oldest daughter to bed every night and we pray," Simpson said. "Once she falls asleep, I've realized what's calmed her is that I start just Googling positive words and I just start talking and then she's out."

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Mariah Carey's Son Moroccan, 9, Reflects on 2020 in Candid Speech: 'Nothing Will Bring Us Down'

Mariah Carey's son is sharing some words of wisdom as he heads into the new year.

On Friday, the 50-year-old singer shared a video on social media of her son, Moroccan, 9, imparting some of his thoughts on 2020 as he looked ahead to 2021.

"Words of wisdom from Rocky for the new year!" the Grammy award-winning singer wrote alongside the post, which also features an appearance from Moroccan's twin sister, Monroe, whom Carey shares with ex Nick Cannon.

Asked by his mother to share what was on his mind, Moroccan wore a festive hat and wished viewers a happy new year, before he began, "A lot of people might've not thought that this year was perfect but this year was inspiring to me … 'Cause I had it too good for too long, man. And I just was like 'Ah, this is so good,' and I needed a jumpstart."

Then, detailing that "this year was really amazing," Moroccan continued, "So many things happened — a lot of good things happened and a lot of bad things happened — but I want to say a lot of stuff with YouTubers, they have not been doing well 'cause of this year."

"But still," he added, "We gotta think good, positive and nothing will bring us down, no matter what."

Carey and her family are currently vacationing in Aspen after the singer and her brood recently embarked on a Christmasy multi-day adventure last month.

The family traveled in style inside a two-bedroom luxury Outdoorsy Prevost Winter Wonderland RV on a trip from Los Angeles to the Colorado locale, arranged by the RV rental company.

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"Let's get festive!" the singer's twins proclaimed in a previously shared video, before everyone hops on board and takes off with their pup — who is shown wearing a variety of headpieces, including reindeer antlers and a flannel floppy-ear hat — in tow.

"So we're on our festive road trip, making our way across the land, celebrating and staying safe. Seeing so many familiar places," Carey explained in the video, which also spotlights the extravagant holiday décor on board.

Earlier this year in October, the "We Belong Together" songstress also opened up about her family's encounters with racism, specifically how Moroccan was bullied by a white supremacist.

Detailing the occurrence during an appearance on Watch What Happens Live, the music icon told host Andy Cohen about the ordeal and related it back to her best-selling memoir, The Meaning of Mariah Carey.

"Rocky just got bullied the other day by a white supremacist person that he thought was his friend," Carey told Cohen, 52, during their chat. "It's like, insane. This is the world we live in."

Though her memoir was completed prior to the current Black Lives Matter movement, Carey — who is biracial — said the book ended up being "so timely" and shared that she was even reading the chapters that touch on race to her two kids.

"I'm reading chapters to them that are helping to illustrate my encounters with racism, and how they can then have a greater understanding, and ultimately a greater reservoir with which to deal with the situation itself," Carey explained.

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Prince William, Duchess Kate Plan to Bring Kids to More Royal Engagements

Looking ahead! Prince William and Duchess Kate have big plans for their eldest two kids’ future royal duties.

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“William and Kate have loved watching Prince George and Princess Charlotte grow and develop over the last year,” a source exclusively reveals in the new issue of Us Weekly. “They have both grown up so much and are little people now rather than kids.”

The insider adds that the duke and duchess, both 38, “hope to be able to take the kids with them on royal engagements” next year, as long as they don’t “interfere” with their Thomas’s Battersea schooling.

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For now, the couple, who are also the parents of son Prince Louis, 2, are enjoying the holiday season with their three children.

“It’s their favorite time of year,” a source exclusively told Us of the little ones last month. “In fact, they’ve already written their list for Santa and are nagging William and Kate to put up the Christmas tree.”

The insider went on to call George “well-behaved,” adding, “All the kids are, but Charlotte and Louis both have a cheeky streak. Louis is more like Charlotte in personality than George!”

While the future king is “obsessed with helicopters, planes and marine biology” and wants to get into diving, “Charlotte loves gymnastics but has recently taken up kids’ yoga.” In fact, she has been teaching her younger brother g and tree pose.

The family of five shared their holiday card earlier this month, and Louis stole the show giggling on his dad’s lap. “The Duke and Duchess are delighted to share a new image of their family, which features on their Christmas card this year,” their Instagram account read.

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The new family photo came one week after William and Kate’s kids made their red carpet debut at The Palladium’s special performance of The National Lottery’s Pantoland, held to honor frontline workers amid the coronavirus pandemic.

For more information on William and Kate’s life at home with three kids, watch the video above and check out the latest issue of Us Weekly, on newsstands now.

With reporting by Travis Cronin

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