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Researcher reports effective treatment for delusional paranoia

Researcher reports effective treatment for delusional paranoia

Professor Daniel Freeman, clinical psychologist, explains how delusions may be unfounded but they cause real distress and misery for sufferers—who feel constantly unsafe. He set himself the challenge of finding an effective treatment, a decade later he and colleagues have unveiled Feeling Safe, which shows real benefits for trial participants and, he hopes, a step change in the treatment of severe paranoia.

A trial participant said, “I was too paranoid about going out. Thinking someone’s going to stab me. I was housebound. Purely just paranoia. I missed out on so many things in life. I’d lie in bed, and I’d be thinking that tomorrow something’s going to happen, something’s going to happen. It would play on my mind 24/7.”

This fear of other people is common among people diagnosed with severe mental health disorders such as schizophrenia. Largely unfounded, often unrelenting, and wearyingly upsetting, these intensely paranoid thoughts are known as persecutory delusions. People feel very unsafe. Also typical is the response: when being out and about is so frightening, staying at home can seem the only way to cope. But there are consequences for both mental and physical health. For example, three quarters of patients with severe paranoia have suicidal thoughts. Life expectancy is on average 14.5 years shorter, due to conditions such as high blood pressure, diabetes and heart disease—illnesses to which inactivity is likely a significant contributory factor.

Given the distress caused by persecutory delusions, treatment is critically important. Usually, people are prescribed anti-psychotic medications. They certainly can help, but only about a quarter of patients have a good response. Moreover, these drugs can trigger unwelcome side-effects. Sometimes medication is combined with psychological treatment—specifically something called cognitive behaviour therapy (CBT) for psychosis. Again, some people get real additional benefit, but all too often the paranoia persists.

There has been, then, plenty of scope for improvement in the treatment of persecutory delusions. So, I set myself an ambitious target: to produce a psychological therapy that would lead to recovery in persecutory delusions for 50% of patients for whom anti-psychotic medication had not succeeded. That half of patients would no longer believe that their fears were true. The Feeling Safe programme, developed with colleagues over the past decade, is the result of that effort.

As you might imagine, developing Feeling Safe has been a long and eventful journey. First, we needed to develop a better understanding of the causes of persecutory delusions. Next, we built and evaluated brief interventions to tackle each of those causes. Finally, we combined those interventions into a new six-month-long treatment. Patients were a crucial part of the design process. And we would not have got far without a succession of UK mental health funders—the National Institute for Health Research (NIHR), the Medical Research Council (MRC), and the Wellcome Trust—stepping up to the plate.

Let’s rewind to the first stage of the treatment development process. What are the causes of persecutory delusions? At the core of the delusion is a threat belief: a conviction that everyday situations are dangerous. Everyday situations have become associated with danger. That threat belief doesn’t appear out of the blue. It is triggered by real-life experiences (bullying, for example, or an assault). But there is likely a genetic vulnerability at work too. Threat beliefs are sustained by what we call maintenance factors: for example, spending lots of time worrying, sleeping poorly, feeling inadequate, and avoiding the situations we fear.

Feeling Safe is fundamentally an effort to counteract and supersede memories of danger by helping the person to relearn that they are safe. To do that, we need to tackle first the key maintenance factors. We help people, for example, worry less, sleep better, and feel more self-confident. Then, ultimately, it’s about spending time in the feared situations with one’s defences lowered, fully engaged in the moment and experience. By so doing, the person can learn that they are, in fact, safe.

Does it work? The results of the first randomised controlled clinical trial of Feeling Safe have just been published in The Lancet Psychiatry. Taking part were 130 patients with persistent persecutory delusions, recruited from NHS mental health services. The form of the trial was intentionally tough: we compared the Feeling Safe Programme to an alternative psychological approach provided by the same therapists. In this way, we could tell if the Feeling Safe programme brings benefits beyond those that come with a positive therapeutic relationship. Patients were assessed before treatment (which typically comprised twenty sessions over a six-month period), after treatment, and six months later.

The results have been as good as I had dared to imagine all those years back. Half of patients at the end of treatment no longer had a persecutory delusion. A further quarter experienced moderate benefit. And those gains largely remained at follow up. Feeling Safe did not only tackle paranoia; it also brought an improvement in patients’ general psychological wellbeing. Crucially, the treatment was very popular: almost everyone stayed the course. Feeling Safe showed large benefits compared to the alternative (and often effective) psychological treatment. The type of therapy we provide to patients really does matter.

Feeling Safe is the most effective psychological treatment for persecutory delusions. But the work does not stop there. The challenge now is to reach the many thousands of people whose lives have disrupted by severe paranoia, and not merely those being treated by our team. We think too that the programme can be improved. Mindful of the quarter of trial participants who did not benefit from Feeling Safe, we will continue to explore alternative therapeutic strategies.

But we are optimistic that we are seeing a step change in the treatment of severe paranoia.

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