Protective effect of CBD in COVID-19
Cannabidiol (CBD) seems to be the occurring cytokine storm and the excessive lung inflammation in severe COVID-19-disorders counteract. CBD may even make negative changes of the lung by COVID-19 undo.
In the current study, the Augusta University, it was found that CBD could affect the treatment results in severe COVID-19-cases, a positive effect. The study was published in the English magazine “Cannabis and Cannabinoid Research”.
ARDS is one of the main causes of death in COVID-19
The Acute Respiratory Distress Syndrome (ARDS or Acute respiratory distress syndrome) in severe cases of some viral infections of the respiratory tract, including COVID-19, one of the main causes of death. There is an urgent need for better Intervention and treatment strategies, is therefore, the researchers describe.
What, exactly, ARDS is?
In acute respiratory distress syndrome is a rapid, severe infection of the lungs, which leads to a widespread inflammation, shortness of breath, rapid breathing and insufficient oxygen supply in the body and brain. Shortness of breath or difficulty in breathing are some of the early signs of COVID-19. ARDS is one of the main causes of death in infections with the Coronavirus SARS-CoV-2.
What CBD is?
CBD is available without a prescription and is used for the treatment of seizures, Parkinson’s and other diseases in which pain and/or inflammation play an important role. It is obtained from the hemp plant. Other research has already shown that the calming effect of CBD can have a positive effect on inflammation.
CBD helps the lungs to recover
Laboratory studies indicate that pure CBD of the lung can be caused help to recover from the inflammation and the cytokine storm, which by the COVID-19 Virus. By treatment with CBD in the body is healthier, oxygen can be values, report the researchers.
CBD reduced inflammation-promoting cytokines
In the new study, the applied model makes use of the large, unique genetic structure of the novel Coronavirus. It’s classic symptoms of ARDS, such as, for example, the destructive simulated immune response. CBD reduced in the model, Pro-inflammatory cytokines. As a result, the oxygen content is improved in the blood and the lung was allowed to recover from structural damage.
SARS-CoV-2 alters the lung
A major problem with SARS-CoV-2 is that the exaggerated immune response, the lungs quickly become unusable. The lung is altered so that the Virus will continue increasing, instead of the body with oxygen and to eliminate potentially harmful gases such as carbon dioxide.
High mortality rate for mechanical ventilation
Mechanical ventilation devices can take over these vital functions for a while and allow critically ill people to use less energy to Breathe and have more energy for fighting infection, while the lungs recover, in the ideal case, explain the researchers. However, there is evidence that 30 to 50 per cent of the COVID-19 affected people do not survive in spite of mechanical ventilation.
What was the impact of the treatment with CBD?
The researchers studied the lung function in mice, by analyzing the content of Pro-inflammatory cytokines, the oxygen content in the blood before and after treatment, as well as the temperature. By treatment with CBD, the Oxygen levels increased and inflammation and cytokine values were. In a later analysis of the lung, a reduction in the key indicators for destructive inflammation could be observed.
How successful is the treatment of mice was that?
The mice were treated in a process developed, the mimic should be what happens in people in treatment if they develop respiratory complaints, and probably medical help would take. CBD led to a rapid improvement of clinical symptoms. Later, detailed studies of the lung showed that the damage to your structure, such as tissue growth, scarring, and swelling, were also abated in whole or in part.
Physical changes have been undone
In fact, both the clinical symptoms and the physical changes in the lungs had been made as a result of ARDS, treatment with CBD reversed, report the researchers.
Further research is needed
An earlier use of the CBD could, however, lead to an impairment of proper immune response against the Virus, the Team explains. In the next steps, the research group is planning similar studies in other COVID-19 affected organs, including the intestine, heart and brain. In addition, further investigations are needed to identify the optimal dosage and the right time to the initiation of the treatment with CBD. (as)