Nick Cannon Is Expecting His 7th Child, a Baby Boy With Alyssa Scott

Another one! Nick Cannon and Alyssa Scott have a baby boy on the way, his seventh child.

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The Wild ’N Out model, 27, posted a photo for Father’s Day of herself and Cannon, 40, at the beach. Though his head is turned away from the camera, the Masked Singer host’s tattoos make his identity clear.

Scott posed in a dark blue sundress while the comedian placed his hands on her belly. “Celebrating you today ❤️,” she wrote via her Instagram Story on Sunday, June 20.

The mother-to-be debuted her baby bump in a since-deleted January Instagram post. “Let’s all gasp together,” she captioned the photo. “SO EXCITED!!”

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Earlier this month, the actress shared a nude maternity shoot photo and captioned the upload with the name “Zen S. Cannon.” Before deleting the picture, she commented her “thanks” to a user congratulating her and Cannon, 40.

The All That alum is already the father of twins Moroccan and Monroe, 12, with Mariah Carey, as well as son Golden, 5, and daughter Powerful, 5 months, with Brittany Bell. He and DJ Abby De La Rosa welcomed twins Zion Mixolydian Cannon and Zillion Heir Cannon on June 14.

In April, De La Rosa, 29, announced that she and the California native were expecting twins. “Our dearest sons: my miracle babies, Thank you for choosing me to be your Mommy. I know the Lord has destined me and prepared me for the gift of not one but two little angels. I pray that God give you both the strength to walk brave and boldly in your individual truth just like your Daddy,” the DJ wrote via Instagram at the time. “That God bless you and your brother and guide you into living out your full purpose.”

The expectant star went on to write, “Your Dad and I will always be here for you both; in complete unison and support. No matter what this world may throw your way, know that forgiveness is key and what is for you — is for YOU! You both are already so loved, and we can’t wait to meet you both.”

She and the Masked Singer host previously suffered a pregnancy loss in June 2020 when De La Rosa was two months along.

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“He was so sweet through it all, reassuring me that what we’ve manifested will come to fruition,” the Masked by La Rose founder wrote via Instagram in January. “Now fast forward to the morning of my birthday — October 25th, I find out that I’m pregnant!!! Then a month later, I found out it was with twins.”

Cannon posed in her maternity shoot photos and also attended De La Rosa’s Club Tummy baby shower. “I especially want to thank Nick,” she wrote alongside party pics in April. “Thank you for your constant love and support.”

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How naked mole rats may help treat cancer, dementia, or Parkinson's

  • Naked mole rats live for over 30 years — much longer than other rodents — without developing degenerative diseases.
  • Their apparent “immunity” to aging is due to unique protective mechanisms that safeguard against DNA damage caused by mutations due to oxidative stress.
  • Scientists believe these unusual creatures may unlock the secret to preventing and treating age-related conditions such as cancer, dementia, or Parkinson’s disease.

The hairless, buck-toothed, and cold-blooded naked mole rat is an unusual animal. It grows to between 3 and 13 inches in length and lives in a complex underground tunnel system beneath the deserts and grasslands of east Africa.

Despite its unusual appearance, the naked mole rat’s most curious feature is its longevity. These animals can live for over 30 years, far beyond the lifespan of other rodents. And seemingly, without the physiological deterioration that affects most older animals.

Scientists now believe that this apparent immunity to aging may hold the secret to preventing and treating aging-related diseases, such as dementia or cancer, in humans.

A biological marvel

Despite their relatively small size, naked mole rats are incredibly hardy. Researchers have studied thousands of these rodents and have rarely, if ever, found them to have cancer. They are also resistant to some types of pain, including pain from insect bites or eating toxic plants, and can survive for up to 18 minutes without oxygen.

“They live remarkably longer than [other] animals of the same size and weight, and they do so without experiencing aging-associated diseases,” Sherif El-Khamisy, a professor of Cancer Therapeutics at the University of Bradford in the United Kingdom and co-author of a recent paper that appeared in the International Journal of Molecular Sciences, told MNT. “Their proficient ability to deal with threats to the genome is remarkable.”

“What we’re trying to do is understand what makes them so resistant and then try to harness that knowledge to come up with new treatments for cancer and conditions [such as] dementia in people.”

Protective mechanisms

As animals age, the body accumulates damage in the form of mutations, which are small changes in the DNA sequence. Mutations can lead to the production of faulty proteins, which disrupt the balance of physical and chemical conditions within the body and cause cells to deteriorate with age – a process called senescence.

In naked mole rats, however, things work a bit differently. The rodents have a superior damage response system that works overtime to repair DNA damage more quickly by cutting out and replacing faulty bases in the DNA sequence.

Even better than repairing damage is preventing it from happening in the first place. Naked mole rats have an extra copy of a gene that promotes antioxidants, which safeguard cells against damage from oxidative stress that can cause mutations. Prof. El-Khamisy and his colleagues believe this could be an adaptation to the low oxygen conditions in naked mole rats’ underground habitat.

Perfecting cell death

In humans, it is the accumulation of senescent cells over time that causes degenerative diseases to develop. For example, blockages that prevent the removal of senescent cells by the immune system are a hallmark of some age-related disorders, including Alzheimer’s disease and Parkinson’s disease.

Interestingly, naked mole rats have far fewer of these age-deteriorated cells.

In most animals, the immune system clears the senescent cells. However, in mole rats, the aged cells die spontaneously, so build-ups never occur.

The end of aging?

Prof. El-Khamisy and colleagues hope that understanding these mechanisms could help pinpoint new targets for treating degenerative conditions and allow humans to tap into the anti-aging abilities of naked mole rats.

“If we can work out how they do this, we could look to adopt similar systems in humans or to use these markers as a predictive tool to be able to say ‘this person is more likely to develop dementia or cancer as they age,’ and then take appropriate steps,” says El-Khamisy.

But aging will probably remain an inevitable part of our lives for the foreseeable future, according to Joao Pedro de Magalhães, a professor of aging and chronic disease at the University of Liverpool in the U.K.

“In terms of translating findings from these extreme animals into humans, I think it’s still early days. We have a glimpse of the longevity and disease resistance mechanisms that these species have, but there is still a lot of work before we can translate it to humans.”

Prof. Magalhães also notes that more research is needed to understand what happens to naked mole rats in later life: “We know very little about causes of death in naked mole rats [as] very few old animals have been studied.”

“They do appear to age,” he says, “Contrary to what you might read.”

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Study Estimates Incidence of Dupilumab-Related Conjunctivitis

One in 15 patients who start dupilumab treatment may develop conjunctivitis during the first 6 months, most of which is manageable with ophthalmic treatments, results from large study of U.S. claims data showed.

“About 4 years after dupilumab’s approval, we’re interested in how conjunctivitis has played out in our daily clinical practice,” lead study investigator Maria C. Schneeweiss, MD, said during the Revolutionizing Atopic Dermatitis symposium.

Drawing from two nationwide U.S. databases, MarketScan and Optum, Schneeweiss, of the department of dermatology at Brigham and Women’s Hospital, Boston, and colleagues sought to characterize the incidence of bacterial and nonbacterial conjunctivitis among 6,730 patients with AD who started treatment with either dupilumab, methotrexate, mycophenolate, or cyclosporine between March 2017 and January 2020. They also wanted to identify patient subgroups at increased or decreased risk of dupilumab-related conjunctivitis in clinical practice.

Of the 6,730 patients, 3,755 started treatment with dupilumab, while 2,010 started with methotrexate, 536 started with mycophenolate, and 429 started with cyclosporine. Using a new-user, active-comparator study design, the researchers identified patients with AD from both databases and selected three dupilumab cohorts: dupilumab versus methotrexate (MTX), dupilumab versus mycophenolate (MMF), and dupilumab versus cyclosporine (CsA). Follow-up lasted 6 months and 1:1 propensity score matching was used to account for conjunctivitis risk factor differences. Patients with a history of conjunctivitis were excluded from the study, except one subgroup limited to those with prior conjunctivitis.

Schneeweiss reported that the overall incidence rate of conjunctivitis within 6 months of treatment initiation was 6.6% in dupilumab users, or 1 in 15 patients, compared with 3.3% in MTX users, 4.2% in MMF users, and 2.8% in CsA users. The incidence rates for the different types of conjunctivitis were as follows:

  • Bacterial conjunctivitis: 1.5% in dupilumab users versus 0.95% in MTX, 0.4% in MMF, and 0.7% in CsA users.

  • Allergic conjunctivitis: 2.2% in dupilumab users versus 0.8% in MTX, 0.2% in MMF, and 1.6% in CsA users.

  • Keratoconjunctivitis: 0.8% in dupilumab users versus 1.1% in MTX, 1.5% in MMF, and 0.5% in CsA users.

In addition, the rate of conjunctivitis requiring ophthalmic medication was 2.6% in dupilumab users versus 0.7% in MTX, 1% in MMF, and 0.5% in CsA users.

After the researchers applied 1:1 propensity score matching, they observed that the risk of conjunctivitis within 6 months of starting treatment was increased in dupilumab users versus MTX users (relative risk, 2.12), dupilumab versus MMF users (RR, 2.43), and dupilumab versus CsA users (RR, 1.83). Among dupilumab users, the risk of conjunctivitis requiring ophthalmic medication was increased six to eightfold, compared with those who used MTX, MMF or CsA. In addition, bacterial conjunctivitis was increased 1.6- to 4.0-fold, compared with those who used MTX, MMF or CsA, but the confidence intervals were wide and included the null, while allergic conjunctivitis was increased 2.7- to 7-fold when compared with those who used MTX and MMF.

In other findings, the risk of allergic conjunctivitis was similar between dupilumab and CsA users (RR, 1.14), and there was no increased risk of keratoconjunctivitis in dupilumab users, compared with those who used MTX, MMF, or CsA. The relative risk of conjunctivitis in those who used dupilumab was further increased when the analysis was limited to AD patients with comorbid asthma (RR, 2.86), those who used systemic glucocorticoids fewer than 30 days prior (RR, 2.88), and those age 65 and older (RR, 2.57), compared with those who used methotrexate.

“Compared to AD patients who received treatment with other systemic agents, dupilumab treatment doubled the risk of conjunctivitis in clinical practice,” Schneeweiss concluded. “Risk factors that further increase the risk include comorbid asthma, use of systemic corticosteroids, and older age. It should be noted that conjunctivitis does not require treatment discontinuation and is manageable with ophthalmic medications.”

Lawrence J. Green, MD, clinical professor of dermatology at George Washington University, Washington, who was asked to comment on the study, said that the work “verifies what we see clinically: that conjunctivitis is increased among dupilumab users even when it is compared to immunosuppressive agents used to treat other conditions. Because the study is retrospective, one cannot assume all diagnosis of types of conjunctivitis or even of skin disease is entirely accurate. But, with the large numbers of claims looked at and compared, one would think its conclusions are accurate.”

Schneeweiss reported having no relevant financial disclosures. Green disclosed that he is a speaker, consultant, or investigator for Amgen, AbbVie, Arcutis, Brickell, Candescent, Cassiopeia, Dermavant, Galderma, Janssen, Forte, Incyte, MC-2, Lilly, Novartis, Novan, Ortho Dermatologics, Revance, Sun Pharma, UCB, and Vyne.

This article originally appeared on MDedge.com, part of the Medscape Professional Network.

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Undiagnosed and untreated disease identified in rural South Africa

Undiagnosed and untreated disease identified in rural South Africa

A comprehensive health-screening program in rural northern KwaZulu-Natal, South Africa, has found a high burden of undiagnosed or poorly controlled non-communicable diseases, according to a study published in The Lancet Global Health.

Researchers found that four out of five women over the age of 30 were living with a chronic health condition, and that the HIV-negative population and older people—especially those over 50—bore the higher burden of undiagnosed or poorly controlled non-communicable diseases such as diabetes and hypertension.

The study was co-led by Emily Wong, M.D., a resident faculty member at the Africa Health Research Institute, or AHRI, in Durban, KwaZulu-Natal, South Africa. Wong is also an assistant professor in the Division of Infectious Diseases, University of Alabama at Birmingham Department of Medicine and an associate scientist in the UAB Center for AIDS Research.

“The data will give AHRI researchers and the Department of Health critical indicators for where the most urgent interventions are needed,” Wong said. “The research was done before COVID-19, but it has highlighted the urgency of diagnosing and treating people with non-communicable diseases—given that people with uncontrolled diabetes and hypertension are at higher risk of getting very ill with COVID.”

Durban lies in the worldwide epicenter for HIV-associated tuberculosis infections. Wong works there to understand the impact of HIV infection—the virus that causes AIDS—on tuberculosis pathogenesis, immunity and epidemiology. She collaborates closely with another UAB researcher who also works at AHRI, Andries “Adrie” Steyn, Ph.D., professor in the UAB Department of Microbiology.

“We are working hard to strengthen ties and collaborations between the two institutions and create a UAB-AHRI Tuberculosis Center that further facilitates multi-disciplinary collaborations,” Wong said. Wong joined UAB last year, and she will spend about 80 percent of her time at AHRI and 20 percent at UAB when travel resumes from its COVID-19 hiatus.

As background to the study, 15 years of intense public health efforts that increased access to anti-retroviral therapy in sub-Saharan Africa has beneficially decreased mortality from AIDS and increased life expectancy. As a result, there is an increasing priority to address other causes of disease, including tuberculosis and non-communicable diseases.

In the 18-month Lancet Global Health study, health workers screened 17,118 people age 15 years and older via mobile camps within 1 kilometer of each participant’s home in the uMkhanyakude district. They found high and overlapping burdens of HIV, tuberculosis, diabetes and hypertension among men and women.

While the HIV cases were, for the most part, well diagnosed and treated, some demographic groups, including men in their 20s and 30s, still had high rates of undiagnosed and untreated HIV. The majority of people with tuberculosis, diabetes or hypertension were either undiagnosed or not well controlled. Tuberculosis remains one of the leading causes of death in South Africa, and the high rates of undiagnosed and asymptomatic tuberculosis that health workers found is a concern.

“Our findings suggest that the massive efforts of the past 15 years to test and treat for HIV have done very well for that one disease,” Wong said. “But in that process, we may have neglected some of the other important diseases that are highly prevalent.”

The mobile camps screened for diabetes, high blood pressure, nutritional status (obesity and malnutrition), and tobacco and alcohol use, as well as HIV and tuberculosis. The tuberculosis screening component included high-quality digital chest X-rays and sputum tests for people who reported symptoms or had abnormal X-rays. Clinical information was layered onto 20 years of population data from AHRI’s health and demographic surveillance research. Through a sophisticated data system and the use of artificial intelligence to interpret the chest X-rays, AHRI’s clinical team examined the information in real time and referred people to the public health system as needed.

Researchers found that:

  • Half of the people 15 years or older had at least one active disease, and 12 percent had two or more diseases. The incidences of diabetes and high blood pressure were 8.5 percent and 23 percent, respectively.
  • One-third of the people were living with HIV, but this was mostly well diagnosed and treated. Women bore a particularly high burden of HIV, high blood pressure and diabetes.
  • For tuberculosis, 1.4 percent of the people had active disease, and 22 percent had lifetime disease. About 80 percent of the undiagnosed tuberculosis was asymptomatic, and men had higher rates of active tuberculosis.

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Diabetes diet: Four diabetes friendly spices to avoid high blood sugar symptoms

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Diabetes is a serious medical condition that causes a patient’s blood sugar levels to become too high. If you have diabetes, you might benefit from cutting back on certain foods, while adding some common spices to your weekly shopping list.

Type 2 diabetes accounts for about 90 percent of all diabetes cases, according to the NHS.

It’s caused by the body not producing enough of the hormone insulin, or the body not reacting to insulin.

Patients should closely monitor their blood sugar levels, because the condition raises the risk of some deadly complications.

One of the easiest way to maintain a normal blood sugar levels – and to avoid unwanted diabetes symptoms – is to change your diet.

Certain spices could lower your risk of diabetes complications, according to food scientist Dr Amitava Sarkar.

For example, black pepper plays a key role in managing diabetes, as well as cholesterol levels, he claimed.

Cardamom has antioxidant and anti-inflammatory properties, which makes it ideal for diabetes management, added the scientist.

Meanwhile, ginger has been claimed to significantly lower fasting blood sugar levels.

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“Diabetes management is a lifelong process,” Dr Sarkar wrote for SastaSundar.

“From taking proper medication, working out daily to following dietary and lifestyle changes, every step is necessary.

“However, did you know that a generous sprinkle of few spices can also help you control diabetes?

“Indian kitchens are a treasure trove of spices that work wonders on our overall health. And the benefits of spices in controlling diabetes are just plenty in number.”

A healthy diet and keeping active will help diabetes patients to manage their blood sugar levels, added the NHS.

There’s nothing you can’t eat if you have diabetes, but you should consider limiting certain foods.

Try to eat a wide-range of foods, including fruit, vegetables, and some starchy foods.

If you need to change your diet plan, or you’re considering adding supplements to your diabetes diet, you should speak to a doctor first.

Many people may have diabetes without even knowing it, because the symptoms don’t necessarily make you feel unwell.

The most common symptoms include feeling very thirsty, having cuts or wounds that take longer to heal than normal, and unexplained weight loss.

You should speak to a doctor if you develop any of the symptoms of diabetes.

A quick blood test should be enough to reveal whether you’re at risk of the condition.

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How I'm Keeping My Lost Dad in My Kids' Lives — On Father's Day & Every Day

I named my son Phoenix because my father died in a town called Phoenix, New York. He died in a fire a year and half before my son was born, and when I thought about the name, the symbolism of a phoenix bird rising from the ash and life beginning again comforted me. Naming my son where my dad died helped my grieving process. When I said the name while looking at my newborn son, it gave me some hope.

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When my daughter Vivian was born a couple of years later, I kept my father’s urn in my son and daughter’s shared bedroom. To their young eyes, they may have thought the urn was just a wooden box with a mountainous landscape carved into it. To me, it was as though my dad could somehow get a chance to experience their squeals of excitement while they toddled around with toy trains and balanced blocks. The urn has continued to remain front and center in our home, now in the living room. I think of it sitting there as a good luck charm, a way to keep him present each day.

When my son was around 3 years old he asked me if I had a dad. I was surprised by his question and simply said, “He passed away.” And then I added, “He is always in our hearts.” I didn’t exactly want to scare my son by saying his grandfather died in a terrible fire, and I didn’t get to say goodbye.

I would look at Phoenix’s arched eyebrow — so much like my father’s — and I didn’t want to tell him that his grandfather was unidentifiable when he died, and the medical examiner said smut was in his lungs, as I held in my grief quietly while driving to the zoo or the children’s museum.

Although my children are 6 and 8 now, I still haven’t gone into great detail about how their grandfather died; they’re still too young for all the details, or maybe I’m just not ready to go there. More importantly, I want them to know their grandfather for his kooky smile and the things he enjoyed and loved to do.

I started sharing facets of my dad with my kids by giving my son a superhero Lego set on Father’s Day. My dad had loved comic books as a kid, something I found out about after he died while talking with his sister. Carrying on his love of superheroes also reminded me of a Superman figure my father gave me when I was a child.

My dad’s favorite candy was a Snickers candy bar, and this treat has become a ritual I share with my kids. I love it when Vivian says, ”Your dad would love this.”

As my kids got older I have shared with them my father’s voice through his preserved voicemails and I share some keepsakes I have, like his Giant’s hat and his sports jacket. After my dad died I created a photo album of just photos of him and it hugs my heart when my kids giggle at his wild and curly hair. Showing these objects to my kids has been a way to introduce my dad, to have an answer when my kids ask about who their grandfather was.

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It hurts knowing my dad would have been a great grandfather — and I know I’m not alone in this feeling and this hurt, on Father’s Day and every day.

“My boys have never met my father. My dad always wanted to be a grandpa and it breaks my heart that they will never get that chance to learn and play with him,” says my friend Shani, a mom of two boys in Larchmont, New York. Her father was an amazing Naval engineer and built ships, and her grandfather and great grandfather also built ships and was a sea captain. She keeps her father’s wisdom alive and shares her dad’s memory with her kids with his anecdotes for life.

“Always follow instructions! When you’re building something, when you’re in school, and in life in general,” Shani says. “You may want to take shortcuts, but if you forget that one important nail, bolt, or screw… you will eventually sink.”

Shani also has taught her boys to be cautious of time, something her father lived by. “He always said being late wastes time, your time and mine,” she says.

Another mom-friend, Charysmel, lost her dad this year and now keeps an orchid —  her father’s favorite — in her home. It warms her heart when her daughter points to it.

“He loved orchids,” she says. “While he and my mom lived in the Dominican Republic prior to his death, they cared for approximately 150 orchids throughout their yard and home. Caring for the orchids became his passion. Right before what would be his last trip to the hospital, he supposedly spoke to his orchids and said, “I love you all and see you later.”

Cooking also keeps memories of her father alive. “When my mom, siblings, and I get together, we always unintentionally tend to cook his favorite foods and randomly tell one of his many stories. This will probably be a common occurrence for our family…forever.”

Although traditions are great, Charysmel says the best way to keep her father’s memory alive is to just speak about him with one another and to my daughter. “We are still healing but I vow to speak of my father and remind my daughter every day of that great man who is her Abuelo.”

Claire Bidwell Smith, a renowned grief expert and author, speaks about the importance of talking about your own loss as a parent with your kids and shares tips for parents who may be unsure of how to bring up their father: “Talking about loss and grief and teaching children ways to remember people we lose will help demonstrate healthy ways of moving through their own inevitable losses in life,” she says. “In years past there were more shrouds of silence surrounding loss and children grew up never really knowing about important family members they may not have met. Incorporating a parent’s memory into your child’s life preserves family lineage, traditions, and generational knowledge.”

Bidwell Smith talks about her own father all the time with her children. “I always make sure to say “Your grandpa Gerry,” instead of “my dad,” so that they have a sense of having two grandfathers, even though only one is living,” she explained. “I tell them stories about his life, and always point out foods he liked, holidays he loved, places he traveled, and traditions we had, so that they have a sense of who he was.”

 

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